Endocrine Disruptor Services

Helping you fulfil the global regulatory requirements for assessment of potential endocrine disrupting substances

In recent years the emerging area of concern for impact on human and environmental health has been the potential for chemical substances and mixtures to affect the endocrine systems of mammals and non-mammalian species.

The effects of certain substances and compounds which inhibit the actions of naturally occurring hormones have become a central point of focus for the scientific community and an area of concern for the wider public.

In response to these concerns Eurofins has been at the forefront of developing specific tests to address the questions that concern the chemical industry, government and non-government organisations and the wider public and prides itself on being the go-to Contract Research Organisation for such tests.

Globally, endocrine disruptors are an area of concern which are being tackled by authorities all over the world with discussions taking place to establish the policies that will regulate the future of ED testing.

In recent years the potential impact of endocrine disruptors has been increasingly regulated on a global scale with a variety of legislative implementations such as one of the first extensive endocrine screening programmes namely the US Endocrine Disruptor Screening Program (EDSP) with specific regulatory triggers highlighted in the Food Quality Protection Act (FQPA) in 1996. More recently European legislation has come into force which specifically mandates that potential disruption of mammalian and non-mammalian endocrine systems need to be considered. These legislation include but not limited to Plant Protection Products (1107/2009), REACH (1907/2006), Biocides (528/2012) and Human Pharmaceuticals. Article 8(3) of Directive 2001/83/EC and associated ERA Guidance EMEA/CHMP/SWP/4447/00 Rev. 1.

These pieces of legislation are supported by guidance documents non regulatory bodies such as the Organisation for Economic and Cooperation and Development (OECD) and World Health organisation (WHO).

The OECD conceptual framework and appropriate testing methods detailed in the "Guidance Document on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption" (OECD Series on Testing and Assessment No 150). This guidance document was originally published in 2012 and updated in 2018 to reflect new and updated OECD test guidelines, as well as reflect on scientific advances in the use of test methods and assessment of the endocrine activity of chemicals. .

In response to this Eurofins Agroscience Services has prioritised Endocrine Disruptor Screening and is able to offer all studies from the physical chemical data through to in vitro approaches and if required complex multigenerational and long term studies with vertebrates and invertebrates.

Eurofins is also poised to support your Endocrine Disruptor testing to confirm and characterise the endocrine effects.

For further information, please contact us.